Cardiovascular Diseases
Cardiovascular DiseasesThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinary Have a look at this page once and make your article mor…
Cardiovascular DiseasesThese topics are filtered from our journals helping to discover the community within the widespread of multi-disciplinary Have a look at this page once and make your article more discoverable in our esteemed journal to ensuring readers find your article through search engines such as Google.
Research Articles
49 articles
Open Access
Research Article 29 Apr 2026
Down-Regulation of Ephrin-B1 in Left Ventricular Non-Compaction
Background: Left Ventricular Non-Compaction (LVNC) is a rare cardiomyopathy with incompletely understood pathophysiological mechanisms. Ephrin-B1 (Ep), a key protein of cardiomyocyte lateral junctions, may play a role in…
7 Views 54 Downloads
Open Access
Research Article 27 Feb 2026
The Development of Acute Kidney Injury and Electrolyte Disorders in Relation to Different Cardioplegic Solutions used during Cardiac Surgery
Background: Acute Kidney Injury (AKI) is a serious complication after cardiac surgery. We sought to determine the possible onset of AKI in patients undergoing cardiac surgery with different cardioplegic solution during C…
13 Views 68 Downloads
Open Access
Perspective 27 Feb 2026
Music as Medicine: Transforming Cardiac Interventions with Physiological and Neurochemical Benefits
Music, deeply embedded in human culture, profoundly influences physiological and psychological states, showcasing remarkable potential within clinical environments, notably the catheterization laboratory (Cath Lab). This…
9 Views 68 Downloads
Open Access
Review Article 08 Oct 2025
The Beneficial Role of Exercise and Whole-Food Plant-Based Diet in Coronary Artery Disease Prevention and Management
Coronary Artery Disease (CAD) remains a critical global health issue, substantially contributing to morbidity and mortality worldwide. The strategic combination of Regular Physical Exercise (RPE) and a Whole-Food Plant-B…
1,686 Views 91 Downloads
Open Access
Clinical Trials 18 Aug 2025
Measuring Nitric Oxide, Reversing Disease and Mitigating Restenosis through Plant-Based Diet and Lifestyle
Once underestimated, Nitric Oxide (NO) is now recognized as a crucial molecule in maintaining vascular health, supporting brain function, and modulating systemic diseases. Since its Nobel Prize-winning discovery in 1998,…
232 Views 76 Downloads
Open Access
Perspective 11 Aug 2025
Harnessing Nutrition to Prevent Coronary Recoil in Drug-Coated Balloon Angioplasty: Insights from Bethsaida Hospital
The success of Drug-Coated Balloon (DCB) angioplasty hinges critically on effectively preventing coronary artery recoil, an acute elastic response that threatens procedural efficacy and long-term vessel patency. While te…
528 Views 79 Downloads
Open Access
Original Article 27 Jul 2025
The Veterans Affairs Lipid Optimization Reimagined - Quality Improvement Program Rationale and Methods
Background: Atherosclerotic cardiovascular disease (ASCVD) is a major contributor to morbidity and mortality in United States (US) Veterans and to healthcare costs in the United States Veterans Affairs (VA) Healthcare Sy…
227 Views 92 Downloads 1 Citation
Open Access
Original Article 09 Jul 2025
Evaluation of the Effect of Ligaria cuneifolia Infusion on Plasma Cholesterol and Liver and Kidney Function in Patients with Cardiovascular Risk
Ligaria cuneifolia (R. et P.) Tiegh. –Loranthaceae– (Lc), commonly used in traditional medicine, is believed to reduce total plasma cholesterol (TC) and improve blood flow. Objective: To evaluate the effect of inges…
7 Views 83 Downloads
Open Access
Opinion 09 Jul 2025
Cracks in the Evidence: Why Studies from COURAGE to ISCHEMIA Failed to Show Benefit of Stenting PCI
Percutaneous Coronary Intervention (PCI) with stenting remains widely utilized for managing Chronic Coronary Syndrome (CCS). However, landmark clinical trials such as COURAGE and ISCHEMIA have repeatedly shown no signifi…
616 Views 74 Downloads
Open Access
Mini Review 30 Jun 2025
Potential Benefits of the Dietary Approaches to Stop Hypertension in Cardiovascular Disease
Cardiovascular Diseases (CVDs) are the leading cause of mortality worldwide and a major public health concern due to their increasing prevalence, economic impact, and association with modifiable lifestyle factors such as…
929 Views 75 Downloads
Open Access
Perspective 30 Jun 2025
Transforming Cardiac Care through Plant-Based Diets: A Breakthrough Experience from Bethsaida Hospital, Indonesia
Seven years ago, at Bethsaida Hospital in Indonesia, Professor Dasaad Mulijono pioneered the integration of a Plant-Based Diet (PBD) into routine cardiac caresa paradigm shift that has dramatically improved outcomes for …
582 Views 85 Downloads
Open Access
Review Article 16 Jun 2025
Modulation of Inflammation in Cardiac Function after Myocardial Infarction
511 Views 77 Downloads
Open Access
Clinical Trials 14 Jun 2025
Gut Microbiota, Cardiovascular Innovation, and Lifestyle Medicine: Southeast Asia’s First Clinical Integration of TMAO Testing
Trimethylamine N-Oxide (TMAO) has emerged as a novel biomarker implicated in the pathogenesis and progression of various cardiometabolic conditions, including Coronary Artery Disease (CAD), stroke, type 2 diabetes mellit…
662 Views 80 Downloads
Open Access
Review Article 28 May 2025
The European Union Must Act Effectively for a New Plan of Action to Improve the Cardiovascular Health Burden of European citizens: A Narrative Review
This Narrative Review presents data describing the health burden of Cardiovascular Disease (CVD) within and across the WHO European Region. CVD remains the most common cause of death in the region. Large disparities in d…
3,140 Views 83 Downloads
Open Access
Short Communication 12 May 2025
Autologous Angiogenic Cell Precursors- A Molecular Strategy for The Treatment of Heart Failure: Response to Biocardia’s Cardiamp HF Trial
508 Views 87 Downloads 1 Citation
Open Access
Research Article 28 Mar 2025
Potential Use of Immunological Indices as Predictors of Bacterial Infections Following Cardiopulmonary Bypass Surgery in Elderly Patients
Cardiac surgery with Cardiopulmonary Bypass (CPB) induces postoperative immunological responses in patients. We aimed to determine changes in various immunological parameters in patients during and after cardiac surgery …
260 Views 140 Downloads 1 Citation
Open Access
Case Report 26 Nov 2024
Tricuspid Stenosis of a Complex Etiology in a 26-Year-Old Woman after Surgical Correction of Congenital Gerbode Defect, successfully treated with Percutaneous Balloon Valvuloplasty
Adults with Congenital Heart Disease (ACHD) are a constantly growing population that often presents significant challenges and requires a multidisciplinary approach. Therapeutic decisions must balance potential benefits …
212 Views 136 Downloads
Open Access
Research Article 06 Jun 2024
Association between Sedentary Behaviors, Tobacco Smoke, Epigenetics, and Cardiovascular Disease
The association between sedentary behavior or physical inactivity and risk for developing vascular aging, Cardiovascular (CVD) or Coronary Artery Disease (CAD) as well as developing risk factors for the disease is high. …
1,169 Views 97 Downloads
Open Access
Research Article 26 Feb 2024
Initial Clinical Experience with New Technology ePatchTM Extended Holter Monitoring
Introduction and objectives: Conventional methods of Holter (H) monitoring, data analysis and reporting can be inefficient, leading to high costs and long response times. Traditional H devices can be cumbersome to wear, …
4,268 Views 104 Downloads
Open Access
Research Article 17 Jan 2024
Risk Factors for Early Bioprosthetic Heart Valve Degeneration in Patients with Rheumatic Fever
Background: Rheumatic Fever (RF) is an immunological disorder related to exposure to group a streptococcus and rheumatic heart disease is an important cause of valve replacement. Bioprosthetic valves tend to degenerate f…
1,124 Views 112 Downloads
Open Access
Research Article 17 Nov 2023
Network Pharmacology Study of Huangqi-Huangjing in the Treatment of Diabetic Nephropathy and Diabetic Cardiomyopathy
Objective: To systematically investigate the mechanism of Huangqi-Huangjing in the treatment of Diabetic Nephropathy (DN) and Diabetic Cardiomyopathy (DC) using network pharmacology and molecular docking analysis. To pro…
1,204 Views 121 Downloads
Open Access
Mini Review 14 Nov 2023
Hypoxic Epicardium Contribution to Myocardial Repair
Epicardium, the outer epithelial layer of the heart forming from extracardiac primordium, plays a fundamental role in myocardial embryogenesis by generating epicardial-derived cells (cardiac fibroblasts, mesenchymal cell…
729 Views 100 Downloads
Open Access
Research Article 25 Oct 2023
TDI Analysis as Predictor of Positive Perugini Score in HFpEF Patients with Restrictive Phenotype
Cardiac amyloidosis is an important but underdiagnosed cause of heart failure with preserved ejection fraction (HFpEF). We analysed TDI doppler with echo to determine if there is a correlation with positive results in my…
744 Views 126 Downloads
Open Access
Research Article 15 Oct 2023
The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil
Background: The novel coronavirus pandemic is an international public health emergency due to the high contagious potential of the virus on a global scale and, similarly to what happened globally, Brazilian authorities t…
3,299 Views 114 Downloads
Open Access
Short Communication 20 Sep 2023
Cardiovascular Complications of SARS-CoV-2 (COVID-19) in Adults
Severe Acute Respiratory Syndrome-2 (COVID-19) was a devastating worldwide pandemic which affected multiple organs, resulting in significant mortality and morbidity. A hallmark of COVID-19 is the ability to mutate and in…
2,719 Views 109 Downloads
Open Access
Mini Review 13 Sep 2023
Prevalence, Predictors and Diagnosis of Cardiac Amyloidosis in Patients with Aortic Stenosis
Cardiac amyloidosis and aortic stenosis often share a common clinical phenotype, and are associated with morbidity and mortality if untreated. Cardiac amyloidosis is present in ~15% of patients with aortic stenosis. Clin…
599 Views 131 Downloads
Open Access
Mini Review 19 Aug 2023
Musculoskeletal Manifestations of Transthyretin Cardiac Amyloidosis
Transthyretin Cardiac Amyloidosis (ATTR-CA) is caused by the deposition of misfolded transthyretin fibrils, leading to restrictive cardiomyopathy and eventually death if untreated. ATTR-CA is associated with certain musc…
1,311 Views 91 Downloads
Open Access
Short Communication 19 May 2023
Subclinical Paroxystic Atrial Fibrillation after Stroke
Stroke is a pathology with great social repercussion, since it is the second cause of mortality in the world and the first cause of dependency in adults [1].…
551 Views 82 Downloads
Open Access
Review Article 30 Mar 2023
Relationship between Ischemic Stroke and Atrial Fibrillation, Systematic Review
Introduction: Atrial Fibrillation (AF) is not only one of the main causes of stroke, but it is also the most common sustained cardiac arrhythmia. As a result of population aging, an increase in the prevalence of AF and o…
435 Views 94 Downloads
Open Access
Review Article 19 Jan 2023
ET-traps: A Potential Therapeutic for Use in Human Complications of the Heart and Kidneys
Endothelin-1 (ET-1) is a potent bioactive mediator that induces vasoconstriction and promotes vascular remodeling. Previous studies indicate that ET-1 plays an important role in the pathophysiology of humans. This includ…
1,537 Views 94 Downloads
Open Access
Case Report 28 Nov 2022
Cancer Patient was attacked by Thrombosis: Case Report
Background: Cancer is the second leading cause of mortality after cardiovascular disease. The second common leading cause of mortality in cancer patients is thrombosis, vary from arterial or venous thromboembolism to dis…
763 Views 79 Downloads
Open Access
Case Report 28 Nov 2022
Successful 4-Year Outcome Following Convergent Ablation for Longstanding Persistent Atrial Fibrillation in an Octogenarian – Novel Therapy for an Old Condition in the Very Elderly
The most common age range for Atrial Fibrillation (AF) prevalence over the coming decades will potentially be in those over 75 years old. However, despite widespread recognition of the strong association between AF burde…
764 Views 70 Downloads
Open Access
Opinion 22 Nov 2022
Budd-Chiari Syndrome: From Clinical to Ultrasonic Diagnosis
Budd-Chiari Syndrome (BCS) is a rare but specific vascular disease. However, the first symptoms of BCS in clinical can be various, such as abdominal pain, lower limb swelling, liver enlargement, etc. BCS is easily misdia…
1,086 Views 78 Downloads
Open Access
Research Article 27 Oct 2022
Research Progress on the Correlation between Hyperhomocysteinemia and Arteriosclerosis Obliteran
Arteriosclerosis Obliteran (ASO) is a local manifestation of systemic arteriosclerosis in the lower extremity arteries. ASO is a chronic progressive disease caused by arteriosclerosis, such as intimal thickening, lumen s…
1,543 Views 78 Downloads 1 Citation
Open Access
Research Article 26 Oct 2022
Effect of Fastigial Nucleus Stimulation on Serum Inflammatory Factors in Patients with Coronary Heart Disease
Objective:
To observe the effect of Fastigial Nucleus Stimulation (FNS) on serum inflammatory
factors in patients with coronary heart disease.
Methods: 144 patients with coronary heart disease were randomly divi…
730 Views 86 Downloads
Open Access
Research Article 30 Sep 2022
Predictors of Acute Response to Cardiac Resynchronization Therapy in Cardiomyopathy Patients
Background: Usefulness of echocardiogram-associated markers for prediction of the response of the patients with cardiomyopathy to Cardiac Resynchronization Therapy (CRT) is under debate.Method: In a cross sectional retro…
684 Views 81 Downloads
Open Access
Case Report 24 May 2022
Perfect is the Enemy of the Good: Outflow Tract Rupture During Self-Expandable Transcatheter Aortic Valve Implantation
Annular rupture is an ambiguous term that refers to a series of infrequent but life-threatening transcatheter aortic valve replacement complications associated with anatomical and clinical risk factors that often require…
1,221 Views 86 Downloads
Open Access
Research Article 30 Apr 2022
Pathophysiology, Treatment and Long-Term Consequences of Heart Failure in Infancy
Introduction: Infants have the highest risk to die from heart failure. However, innovations like beta-blocker treatment introduced more than 50 years ago are not recorded in the guidelines if the clinical trials are miss…
1,489 Views 88 Downloads
Open Access
Review Article 26 Apr 2022
Exposure to Urban Air Pollution Nanoparticles: Oxidative Stress and Cardiovascular Disease
It is estimated that more than two-thirds of air pollution-related deaths are due to cardiovascular causes. Significant studies have now indicated that exposure to urban air pollutants is known to be a source of oxidativ…
3,255 Views 89 Downloads 2 Citations
Open Access
Review Article 16 Apr 2022
Association of Myocardial Infarction Among Cervical Cancer Patients
Introduction: Increased risk of myocardial infarction has been validated for several cancers, but limited study evaluated this risk in cervical cancer patients. Our study aimed to evaluate the risk of myocardial infarcti…
1,862 Views 51 Downloads
Open Access
Case Report 08 Mar 2022
Lead Extraction and Re-Extractions - Inherent Parts of Permanent Pacing in Children and Young Adults
Children require often replacement of leads even several times. Repeated extraction in this group nay be challenging. We report the case of a 22-year-old man with the first pacemaker implanted in the first year of life, …
2,347 Views 86 Downloads 3 Citations
Open Access
Case Report 31 Jan 2022
Haemolytic Anaemia Due to Early Failure of Mitral Valve Repair with Artificial Neochordae: A Technical Error
We report the case of an unexpected massive haemolysis occurred early after mitral valve repair. Potential underlying causes have been investigated, with review of the literature. After mitral valve replacement, haemolys…
1,459 Views 98 Downloads 1 Citation
Open Access
Case Report 26 Jan 2022
Right Atrial Myxoma in Patients with Metastatic Breast Cancer: Multidisciplinary Approach and Surgical Timing
Primary cardiac tumours are very rare. We describe the case of a 69-year-old female suffered from metastatic breast cancer and intestinal polyposis. During periodical follow-up examinations, total body Computed Tomograph…
1,733 Views 83 Downloads
Open Access
Case Report 26 Jan 2022
Simultaneous Operation on Pump Coronary Bypass Grafting and Left Hemicolectomy in Patient with Reduced Ejection Fraction
This is written so as to report the case of a 75-year-old male with a diagnosis of sigmoid adenocarcinoma accompanied by critical coronary artery disease and angina, which was subject to simultaneous surgical treatment. …
1,334 Views 92 Downloads
Open Access
Mini Review 21 Dec 2021
Placental Exosomes Trigger Maternal Inflammation and Vascular Dysfunction in Preeclampsia
Preeclampsia is a pregnancy-specific disease associated with inadequate placental formation, chronic inflammation, and maternal vascular dysfunction. Preeclampsia affects about 5-8% of pregnant women and it is a prevalen…
8 Views 80 Downloads
Open Access
Original Article 21 Jul 2021
Assessment of Nanosilver Hemocompatibility in Prehypertensive Salt-Induced Animal Model
Aim: There are Conflicting reports on safety profile of nanoparticles on biological cells. This study evaluated the impact of nanosilver on hemocompatibility on salt-loaded rats.Materials and Methods: Sprague-Dawley rats…
1,426 Views 77 Downloads
Open Access
Case Report 29 Jun 2021
Inducible Atrial Fibrillation and Myocardial Ischemia in a Veteran Amateur Runner: An Anecdotal Case Report
Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with significant morbidity and mortality. Coronary artery disease frequently coexists with AF, and management of these associated cond…
1,710 Views 141 Downloads
Open Access
Editorial 11 Jan 2021
Multifaceted Medical and Scientific Approaches and the Role of the Public in Combating the COVID-19 Pandemic in the Digital Era
Epidemics and pandemics have been recurrent in history. One of the worst pandemics in the modern history was the 1918 H1N1 flu (“Spanish fluâ€) that claimed the lives of an estimated 50 million people globally [1]. Th…
5,610 Views 292 Downloads
Open Access
Clinical Study 18 Sep 2020
Patient Demographics Associated with ARDS Incidence, Hospital Length of Stay and Mortality
Introduction: Acute Respiratory Distress Syndrome (ARDS) is a common finding among pediatric and adult patient populations [1]. ARDS-related mortality remains high and is associated with prolonged hospital Length of Stay…
3,034 Views 466 Downloads
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